Resident Evil Requiem is the latest entry in the survival horror series from CAPCOM, and the biggest shift for the franchise since the days of Resident Evil 4. While the game maintains the series' signature atmosphere and resource management, the introduction of a dual-narrative system featuring Grace Ashcroft and Leon S. Kennedy deeply changes gameplay, offering both intense survival-horror sequences focused on stealth and enemy avoidance, and full-on action combat.
In this Complete Walkthrough and Guides Hub, you will find everything you need to survive the horrors Grace and Leon will encounter as they face their past.
Table of contents
Overview
Resident Evil Requiem is a hardcore survival-horror game which blends the gameplay styles of the survival horror-focused Resident Evil 7 Biohazard with the full-on action experience of Resident Evil 4, in which players control two protagonists as they navigate a variety of different locations, including some iconic returning locations from previous entries in the series, solve puzzles and defeat enemies.
To help you get started, you can check out the following guides:
Story Progression and Puzzles
Like previous entries in the series, Resident Evil Requiem is a linear experience where you have to explore a variety of intricately designed locations filled with enemies to defeat and puzzles to solve. Still, these locations feature many optional segments that include additional items and resources that can make quite a big difference during the most intense fights.
Rhodes Hill Care Center Puzzles
- Chairman's Office Puzzle Box Combination
- Lead Researcher's Office Puzzle Box Combination
- How to Open the Organ Box
Optional Puzzles
- How to Open Warped Closets
- Care Center Bar and Lounge, Examination and Basement Safes Codes
- ARK Sterilization Chamber and Monitor Control Room Safes Codes
Endings
Combat And Stealth
The most significant change in Resident Evil Requiem is the combat flow for the two protagonists. Grace Ashcroft, a fragile FBI investigator, must rely on stealth and careful picking of her fights as she tries to stay ahead of all sorts of mutated monsters. Meanwhile, the battle-hardened Leon S. Kennedy has the skills and tools to face these enemies head-on, his gameplay segments building on the mechanics seen in Resident Evil 4 and its remake.
Mechanics
Bosses
Character Progression
In true survival-horror fashion, character progression in Resident Evil Requiem is tied to the item system. Both Grace and Leon can find items as they explore different locations to improve their item carrying capacity, firepower, and, in Grace's case, health and shooting abilities.
Upgrades
Crafting System
Resident Evil Requiem features a crafting system that allows Grace and Leon to use resources to craft useful items such as additional ammo, healing injectors, and more. To unlock more crafting recipes, however, you will need to use Blood Specimen and analyze them by completing simple puzzles governed by some special rules.
Special Content
In true series fashion, Resident Evil Requiem features plenty of special content ranging from new weapons and charms with passive skills to costumes, concept art, and 3D models that can be unlocked by either spending Completion Points, obtained by clearing in-game challenges, finding certain collectibles, and more
Cosmetics
Collectibles
Review
In case you are still on the fence, check out our Resident Evil Requiem review to learn if this is a game worth your money and time. If you're playing the game on PC, check out our Performance Analysis and Tuning guide for the best graphics settings.
All guides are based on a full playthrough completed at the Standard (Classic) difficulty in the Steam 1.0 version. Screenshots captured from the same version.
Last updated: February 27, 2026
About the author: Francesco De Meo has been covering video games and technology since 2012, starting his career at small outlets like Gamersyndrome and GeekSnack. After joining Wccftech gaming section in 2015, he quickly expanded his video gaming coverage with in-depth reporting, interviews with iconic industry figures such as Grasshopper Manufacture founder and No More Heroes creator Goichi "Suda51" Suda, Resident Evil series creator Shinji Mikami, Team NINJA's president and Nioh series director Fumihiko Yasuda, and Silent Hill creator Keiichiro Toyama, reviews and on-the-ground coverage of major industry events such as Gamescom and E3. When he's not reporting or reviewing, Francesco can be found playing the genres he loves most, spending time with his six cats, reading, writing music, playing guitar and drumming for his progressive rock band.
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