If you played and ended the first Darksiders you will probably understand what the narrator in the trailer is talking about, about how the end of the world was brought about pre-maturely and how War was framed for it happening well this time Death won't take liars as lightly as War did and Death is out for revenge against those who setup his brother.
Not many game developers have ever done a bold move such as making a game based on the four horsemen of the apocalypse and market it as a commercial success, Darksiders did the very thing and it had a very positive response from the community on it's release on the consoles and later on the PC. Darksiders lets us play as War who is one of four horsemen of the apocalypse but when the end of the world is brought about earlier than its supposed to be War is framed guilty for this and he sets out on proving his innocence.
While War never did get the justice he deserved its up to the infamous horsemen of Death to do so for him and eventually clear Wars name once and for all as the tag line in the trailer goes to show us "What Starts With War, Ends Wtih Death". Darksiders 2 is coming out in 2012 for the PC, PS3 and the XBOX 360 and is probably one of my most anticipated sequel right along Mass Effect 3 and Bioshock Infinite. The entire trailer is amazing as it shows the constant of change of Water to Blood and back and how it trickles down Deaths scythe so slowly creating a real nice effect and the overall appearance of Death is really suiting to someone of his nature and background.