The upcoming AMD Zen 6 CPUs may not support the standard A1B1 memory orientation and some motherboard manufacturers like MSI have already started preparing newer versions of their existing 800 series motherboards.
Uniko's Hardware Gets a Different MPG B850i Edge Ti WiFi That Boasts DIMMA2/DIMMB2 Instead of DIMMA1/DIMMB1 for Memory, Design Change Possibly Indicates Support for AMD's Upcoming Zen 6 CPUs
A few months back, we reported that the AMD Zen 6 processors may not support the traditional DIMM orientation, which is due to some changes to the Integrated Memory Controller on the I/O die of these chips. More solid reports are now surfacing online, suggesting that the change is real, and once again, Unkio's Hardware has come up with a new report, which lends more weight to this rumor.
The current 800-series lineup of motherboards, especially those with only two DIMMs, comes in DIMMA1 and DIMMB1 memory configurations. MSI's MPG B850i Edge Ti WiFi has reportedly been created with two different orientations, if we consider Uniko's newest report. While the one that is launched for consumers uses the DIMMA1/DIMMB1 configuration, Uniko received the one with "DIMMA2/DIMMB2", which is unusual to see on a 2-slot motherboard.

Going by the previous report, this indicates that the rumor about Zen 6 featuring two IMCs might be true, and this will require pre-positioning the slots to match the CPU memory controller alignment on Zen 6. As far as how these two IMCs will be deployed on Zen 6 processors.
However, the A2B2 memory configuration is a rare sight on two-slot motherboards, but we may see more such upgraded boards in the near future. Once again, this also confirms Zen 6 support on the AM5 platform indirectly.
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